Optimizing your Celo Sage workflow with Trello Power-Ups can have a significant impact on your Web3 development process. By using power-ups to automate tasks, improve project management, and enhance team collaboration, this would allow you to streamline your workflow and increase your efficiency. The benefits of using Trello Power-Ups for Celo Sage developers include improved task management, better organization of project-specific information, and enhanced team communication.